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Enterococci are part of the normal intestinal flora of people and other animals. They are also recognised as pathogens, causing a wide variety of conditions from urinary tract infections to life-threatening systemic infections such as bacteraemia, endocarditis and meningitis. However, in recent years enterococci have become increasingly difficult to treat because of an increase in the number of species showing antibiotic resistance. Vancomycin is the drug of choice for most enterococcal infections, although in some settings the intravenous form of the drug, which is clearly more expensive than oral versions, is preferred. Resistance to vancomycin is mediated by vancomycin-resistant enterococci (VRE). They are commonly found in the intestines and faeces of people, domestic animals and wildlife. The resistance genes that have been isolated, in some cases from a few isolates, can be carried on different plasmids and transposons which probably play a significant role in the dissemination of resistance. Enterococci that are resistant to both penicillin and tetracycline are referred to as multiply resistant enterococci. There are, to date, little evidence for a clonal dissemination of multiply resistant enterococci in the UK. The behaviour of multiply resistant enterococci can be influenced by the presence of VRE within it. Resistance to beta-lactams, aminoglycosides and macrolides can be disseminated by non-hypermutable high-level resistance and VRE. This situation can lead to treatment failure. In this case VRE can be transient, only a small proportion of which would have the necessary genotype to persist within a multiply resistant strain. By growing multiply resistant enterococci an enrichment of the resistant population can occur leading to an increase in the persistence of VRE. Several in vitro and in vivo studies have demonstrated that the acquisition of resistance genes and traits of VRE can promote the emergence of multiply resistant enterococci. The potential of this behaviour to promote a higher level of bacterial resistance and persistence needs to be studied more comprehensively.Q: SQLite COUNT(*) causes Query Selectivity Issues I'm having issues with a SELECT statement that's returning a result-set with an unexpectedly high record count. The following SQLite query is creating a result-set of 30K+ records when the table contains What's New In Adobe Photoshop CS6? 1. 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It was not immediately clear if the metal that fell off the train was the cause, but the Australian Railway Association says metal can fall off rail tracks and cause deadly accidents. Metro says it was still investigating the reasons for the incidents but was "not ruling out anything," AP reports. Passenger numbers in the O'Shannassy area on the outer edge of Melbourne have been slashed by 60%. On Thursday, a driver of a lorry was killed when a car smashed into the vehicle and a concrete pillar. "There's no rhyme or reason as to why this would happen," the Transport Safety Victoria chief says. 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